Researchers from Faculty of Biology and A.N. Belozersky Institute of Physico-Chemical Biology (Lomonosov Moscow State University) tested a mitochondria-targeted antioxidant that helps to treat diabetic wounds. This statement was made on Lomonosov Moscow State University website on June 16, 2017. The results of the investigation were published in Oxidative Medicine and Cellular Longevity Journal.
One of the symptoms of the type II diabetes is delayed wound healing. In particular, wounds develop on legs of the patients. This phenomenon is called a diabetic foot. Such wounds are complicated to treat and they are of chronic type. Usually the only way to treat them is a surgery.
It is supposed that one of the reasons of delayed wound healing is diabetic angiopathy, an abnormality of vessel functions, which is caused by oxidative stress due to the diabetes.
In their work the researchers tested the effectiveness of mitochondria-targeted antioxidant, SkQ1, on mice. Using molecular, biological, biochemical, immunological, and histological approaches, they found out that SkQ1 normalizes almost all main stages of wound healing, it accelerates the wound epithelization and formation of granulation tissue, stimulates the growth of vessels, rehabilitates the disturbed circulation. According to scientists, this proves an important role of mitochondrial active oxygen forms in pathogenesis of diabetic wounds.
'From the practical point of view, the obtained results together with the data on safety of local administration of SkQ1 could be used for creation of effective drug for diabetic wound healing. Such a drug could be a peroral preparation for systemic use or a wound healing gel that could be used on damaged skin', one of the authors of the investigation Dr. Roman Zinovkin (Lomonosov Moscow State University) said.
Lomonosov Moscow State University (http://www.msu.ru/) is a coeducational and public research university located in Moscow, Russia.
The A.N. Belozersky Institute of Physico-Chemical Biology (http://www.belozersky.msu.ru) is one of the major research and educational units of the Lomonosov Moscow State University. More than twenty departments of the Institute are performing research in modern biochemistry, biophysics, molecular biology, molecular virology, cell biology, biomedicine, genomics, proteomics, and bioinformatics.